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Saturday, May 2, 2020 | History

2 edition of The BDII rat model of endometrial cancer found in the catalog.

The BDII rat model of endometrial cancer

Ahmad Hamta

The BDII rat model of endometrial cancer

molecular analysis of genetic and cytogenetic aberrations

by Ahmad Hamta

  • 31 Want to read
  • 3 Currently reading

Published by Department of Cell and Molecular Biology-Genetics, Lundberg Institute, Göteborg University in Göteborg .
Written in English

    Subjects:
  • Endometrial neoplasms,
  • Chromosome abnormalities,
  • Rats

  • Edition Notes

    Other titlesThe BD2 rat model of endometrial cancer.
    StatementAhmad Hamta.
    Classifications
    LC ClassificationsRG316 .H36 2006
    The Physical Object
    Pagination1 v. (various pagings) :
    ID Numbers
    Open LibraryOL23916839M
    ISBN 109162868152
    ISBN 109789162868154
    LC Control Number2006455279

    In the BDII rat model, for endometrial cancer both Cdk6 and Met were amplified frequently in the EAC tumors, but there was no amplification of the Tac1 gene, in spite of its location between the two amplified genes. In fact, there were indications of Tac1 deletion in the rat model,.Cited by: The similarities in physiology and pathogenesis between rats and humans imply that the BDII rat strain is a suitable model for analysis of human endometrial cancer. MicroRNAs (miRNAs) are small RNA molecules that regulate gene expression by inhibition of protein translation or Cited by: 6.

      The endometrial carcinogenesis in the females of the BDII rat strain is hormone dependent and represents an outstanding model for spontaneous hormonal carcinogenesis. [ 4 – 6 ] Genomic approaches such as gene expression profiling by DNA microarrays, provide unprecedented tools to handle the complexity of cancer at the transcriptional by: 8. The BDII/Han inbred rat model, first described in , is genetically well characterized and has since then become a useful model for studies of human endometrial adenocarcinoma. More than 90% of the female BDII/Han virgins spontaneously develop EC during their life time, where the majority of the neoplasms are by: 8.

    (). G: Cytogenetic aberrations in spontaneous endometrial adenocarcinomas in the BDII rat model as revealed by chromosome banding and comparative genome hybridization. Cancer Genetics and Cytogenetics (). Garin-Chesa P: Immunohistochemical detection of bone morphogenic proteins in bone and soft-tissue sarcomas.   1. Introduction. Endometrial cancer (EC) accounts for % of all cancers diagnosed in women and is the fifth most common type of cancer in developed countries [1,2,3].It is the most common malignancy of the female reproductive tract, with a cumulative risk of 1% by age of 75 years, while the death risk is % [1,2,3].Around , new cases are diagnosed yearly worldwide, Cited by: 6.


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The BDII rat model of endometrial cancer by Ahmad Hamta Download PDF EPUB FB2

Deerberg F, Kaspareit J () Endometrial carcinoma in BDII/Han rats: model of a spontaneous hormone-dependent tumor. J Natl Cancer Inst –Author: Karin Klinga-Levan, Göran Levan.

Females of the BDII inbred rat strain are extremely prone to endometrial adenocarcinoma, (EAC) and approximately 90% of virgin females spontaneously develop EAC during their life span. Thus, these rats serve as a useful model for the genetic analysis of this by: 7.

The BDII/Han rat model is unique for spontaneous hormonal carcinogenesis since more than 90% of the female virgins spontaneously develop endometrial cancer. The possibility to perform global gene expression profiling of tumor cells would likely provide.

The BDII inbred rat strain is known to be genetically predisposed to endometrial carcinoma.5, 6 With few exceptions, endometrial carcinomas are uncommon findings among rats, but more than 90% of virgin BDII females will develop malignant uterine tumors before 2 years of age.

Similar to all cancer diseases, endometrial cancer is a disorder that results from complex patterns of genetic and epigenetic alterations involved in the malignant transformation.

The BDII/Han rat model is unique for spontaneous hormonal carcinogenesis since more than 90 % of the female virgins spontaneously develop endometrial cancer. BDII rat model of endometrial adenocarcinoma cells.

Quantitative real-time PCR was used to analyze expression levels of MAP2K1 and CCND1 genes in BDII/Han rat model of endometrial cancer cells using TaqMan approach. Characteristics Frequent microphthalmia. Genetic markers described for sublines of this strain in the USA differ from those in Europe, suggesting that the US sublines were contaminated at some time in the past with LEW (Czerwinski and Crowell ).Mean life-span of BDII/Han _ months in males and _ months in females, with 91% of females developing endometrial carcinomas, but with.

The BDII/Han inbred rat strain model serves as a good model for human endometrial cancer because of its similarities to the cell biological aspect of pathogenesis in humans and the fact that 90 % Author: Umer Naveed Chaudhry. The BDII/Han rat develops spontaneous endometrial adenocarcinoma, which appears virtually identical histologically to human endometrial adenocarcinoma.

The This animal model therefore, is useful in the study of molecular aspects of spontaneous transformation as well as mammalian neoplastic by: 9. A powerful model of endometrial carcinogenesis System Biology workshop, NovemberBild 2 Outlines!.

Uterine tumors!. Endometrial cancer (EC)!. A relevant tumor model for EC!. The BDII rat tumor model!. Recent Molecular data!. Development of this model.

In the present work we used spectral karyotyping (SKY) to identify cancer-related aberrations in a well-characterized experimental model for spontaneous endometrial carcinoma in the BDII rat tumor model. Analysis of 21 experimental ECs revealed specific nonrandom numerical and structural chromosomal by: 4.

The endometrial tumor model is composed of the BDII rat strain, predisposed to spontaneously develop endometrial cancer. Tumors obtained from progeny from intercrosses. The endometrial carcinogenesis in female BDII/Han rats is hormone dependent and thus represents an excellent model for spontaneous hormonal carcinogenesis.

The BDII rat model is genetically well characterized and has become a recognized model for analyzing the genetic changes involved in endometrial carcinoma tumorigenesis [7], [8], [9].Cited by: 6. The BDII inbred rat strain has been used as a powerful tumor model in studies of the genetic background of EAC.

Females from the BDII strain are prone to develop tumors with an incidence of. The data from this investigation were used to analyze a set of human endometrial tumors for amplification of Cdk6 and Met. Our preliminary data are indicative for a good correlation between our findings in the BDII rat model for EAC and the situation in human EC.

These data provide strong support for the use of animal model systems for better Cited by: Abstract Rat BDII model used to understand endometrial adenocarcinoma study.

Endometrial carcinoma recognized as a third most common cause of death in the females : Dr Shahid Mehmood Qureshi. Two genetic alterations that have been reported from human endometrial cancer are amplification of the ERBB2 gene and mutations in the 12 codon of the KRAS gene.

One case of Erbb2 amplification was found but there were no Kras mutations in the rat material studied. We conclude that molecular genetic analysis of the rat BDII model will provide Cited by: The BDII/Han rat model is unique for spontaneous hormonal carcinogenesis since more than 90% of the female virgins spontaneously develop endometrial cancer.

The possibility to perform global gene expression profiling of tumor cells would likely provide important information of the genes and pathways that are aberrant in endometrial adenocarcinoma (EAC).

Quantitative real-time PCR was used to analyze expression levels of MAP2K1 and CCND1 genes in BDII/Han rat model of endometrial cancer cells using TaqMan approach. The differences in gene expression levels of MAP2K1 and CCND1 between pathologically EAC malignant and nonmalignant cells showed an upregulation of MAP2K1 and CCND1 in EAC malignant : Almir Budnjo.

The BDII inbred rat strain has been used as a powerful tumor model in studies of the genetic background of EAC. Females from the BDII strain are prone to develop tumors with an incidence of more than 90%.

Hamta A, Adamovic T, Helou K, Levan G. Cytogenetic aberrations in spontaneous endometrial adenocarcinomas in the BDII rat model as revealed by chromosome banding and comparative genome hybridization. Cancer Genetics and Cytogenetics. ; – doi: /gencytoCited by: 4.The BDII Rat Model of Endometrial Cancer: Molecular Analysis og Genetic and Cytogenetic Aberrations.

By Ahmad Hamta. Topics: cancer, animal model, BDII rat, endometrial cancer Author: Ahmad Hamta. Endometrial adenocarcinoma is the most frequently diagnosed cancer of the female genital tract in the western world.

Studies of complex diseases can be difficult to perform on human tumor samples due to the high genetic heterogeneity in human. The use of rat models is preferable since rat has similarities in pathogenesis and histopathological properties to that of by: 9.